Pathology of the liver sinusoids
Identifieur interne : 003D51 ( Main/Exploration ); précédent : 003D50; suivant : 003D52Pathology of the liver sinusoids
Auteurs : Elizabeth M. Brunt [États-Unis] ; Annette S H. Gouw [Pays-Bas] ; Stefan G. Hubscher [Royaume-Uni] ; Dina G. Tiniakos [Grèce, Royaume-Uni] ; Pierre Bedossa [France] ; Alastair D. Burt [Australie] ; Francesco Callea [Italie] ; Andrew D. Clouston [Australie] ; Hans P. Dienes [Autriche] ; Zachary D. Goodman [États-Unis] ; Eve A. Roberts [Canada] ; Tania Roskams [Belgique] ; Luigi Terracciano [Suisse] ; Michael S. Torbenson [États-Unis] ; Ian R. Wanless [Canada]Source :
- Histopathology [ 0309-0167 ] ; 2014-06.
Abstract
The hepatic sinusoids comprise a complex of vascular conduits to transport blood from the porta hepatis to the inferior vena cava through the liver. Under normal conditions, portal venous and hepatic artery pressures are equalized within the sinusoids, oxygen and nutrients from the systemic circulation are delivered to the parenchymal cells and differentially distributed throughout the liver acini, and proteins of liver derivation are carried into the cardiac/systemic circulation. Liver sinusoid structures are lined by endothelial cells unique to their location, and Kupffer cells. Multifunctional hepatic stellate cells and various immune active cells are localized within the space of Disse between the sinusoid and the adjacent hepatocytes. Flow within the sinusoids can be compromised by physical or pressure blockage in their lumina as well as obstructive processes within the space of Disse. The intimate relationship of the liver sinusoids to neighbouring hepatocytes is a significant factor affecting the health of hepatocytes, or transmission of the effects of injury within the sinusoidal space. Pathologists should recognize several patterns of injury involving the sinusoids and surrounding hepatocytes. In this review, injury, alterations and accumulations within the liver sinusoids are illustrated and discussed.
Url:
DOI: 10.1111/his.12364
Affiliations:
- Australie, Autriche, Belgique, Canada, France, Grèce, Italie, Pays-Bas, Royaume-Uni, Suisse, États-Unis
- Angleterre, Attique (région), Groningue (province), Latium, Maryland, Midlands de l'Ouest, Vienne (Autriche)
- Athènes, Baltimore, Birmingham, Groningue, Rome, Vienne (Autriche)
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Brunt</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Immunology, Washington University, School of Medicine, MO, St Louis</wicri:regionArea><wicri:noRegion>St Louis</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Gouw, Annette S H" sort="Gouw, Annette S H" uniqKey="Gouw A" first="Annette S H" last="Gouw">Annette S H. Gouw</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Hubscher, Stefan G" sort="Hubscher, Stefan G" uniqKey="Hubscher S" first="Stefan G" last="Hubscher">Stefan G. Hubscher</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cellular Pathology, Queen Elizabeth Hospital Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Tiniakos, Dina G" sort="Tiniakos, Dina G" uniqKey="Tiniakos D" first="Dina G" last="Tiniakos">Dina G. Tiniakos</name><affiliation wicri:level="3"><country xml:lang="fr">Grèce</country><wicri:regionArea>Laboratory of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Current Address: Department of Pathology, Newcastle University, Royal Victoria Infirmary, NE1 4LP, Newcastle Upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle Upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Bedossa, Pierre" sort="Bedossa, Pierre" uniqKey="Bedossa P" first="Pierre" last="Bedossa">Pierre Bedossa</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Hopital Beaujon, Service d'Anatomie Pathologique, Clichy</wicri:regionArea><wicri:noRegion>Clichy</wicri:noRegion><wicri:noRegion>Clichy</wicri:noRegion></affiliation></author><author><name sortKey="Burt, Alastair D" sort="Burt, Alastair D" uniqKey="Burt A" first="Alastair D" last="Burt">Alastair D. Burt</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>University of Adelaide School of Medicine, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Callea, Francesco" sort="Callea, Francesco" uniqKey="Callea F" first="Francesco" last="Callea">Francesco Callea</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale Pediatrico Bambino Gesu, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Clouston, Andrew D" sort="Clouston, Andrew D" uniqKey="Clouston A" first="Andrew D" last="Clouston">Andrew D. Clouston</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Liver Disease Research, School of Medicine (Southern), University of Queensland, Princess Alexandra Hospital, Woolloongabba</wicri:regionArea><wicri:noRegion>Woolloongabba</wicri:noRegion></affiliation></author><author><name sortKey="Dienes, Hans P" sort="Dienes, Hans P" uniqKey="Dienes H" first="Hans P" last="Dienes">Hans P. Dienes</name><affiliation wicri:level="3"><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Pathology, Meduniwien, Medical University of Vienna, Wien</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Goodman, Zachary D" sort="Goodman, Zachary D" uniqKey="Goodman Z" first="Zachary D" last="Goodman">Zachary D. Goodman</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Liver Diseases, Inova Fairfax Hospital, VA, Falls Church</wicri:regionArea><wicri:noRegion>Falls Church</wicri:noRegion></affiliation></author><author><name sortKey="Roberts, Eve A" sort="Roberts, Eve A" uniqKey="Roberts E" first="Eve A" last="Roberts">Eve A. Roberts</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, ON, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Roskams, Tania" sort="Roskams, Tania" uniqKey="Roskams T" first="Tania" last="Roskams">Tania Roskams</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Histo‐Cytochem, University Hospital St Rafael, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Terracciano, Luigi" sort="Terracciano, Luigi" uniqKey="Terracciano L" first="Luigi" last="Terracciano">Luigi Terracciano</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pathology, University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Torbenson, Michael S" sort="Torbenson, Michael S" uniqKey="Torbenson M" first="Michael S" last="Torbenson">Michael S. Torbenson</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University School of Medicine, MD, Baltimore</wicri:regionArea><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Current Address: Anatomic Pathology, Mayo Clinic, Hilton 11, 200 First Street, SW, MN, 55905, Rochester</wicri:regionArea><wicri:noRegion>Rochester</wicri:noRegion></affiliation></author><author><name sortKey="Wanless, Ian R" sort="Wanless, Ian R" uniqKey="Wanless I" first="Ian R" last="Wanless">Ian R. Wanless</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology, Dalhousie University, Queen Elizabeth II Health Sciences Centre, NS, Halifax</wicri:regionArea><wicri:noRegion>Halifax</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Histopathology</title><title level="j" type="alt">HISTOPATHOLOGY</title><idno type="ISSN">0309-0167</idno><idno type="eISSN">1365-2559</idno><imprint><biblScope unit="vol">64</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="907">907</biblScope><biblScope unit="page" to="920">920</biblScope><biblScope unit="page-count">14</biblScope><date type="published" when="2014-06">2014-06</date></imprint><idno type="ISSN">0309-0167</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0309-0167</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The hepatic sinusoids comprise a complex of vascular conduits to transport blood from the porta hepatis to the inferior vena cava through the liver. Under normal conditions, portal venous and hepatic artery pressures are equalized within the sinusoids, oxygen and nutrients from the systemic circulation are delivered to the parenchymal cells and differentially distributed throughout the liver acini, and proteins of liver derivation are carried into the cardiac/systemic circulation. Liver sinusoid structures are lined by endothelial cells unique to their location, and Kupffer cells. Multifunctional hepatic stellate cells and various immune active cells are localized within the space of Disse between the sinusoid and the adjacent hepatocytes. Flow within the sinusoids can be compromised by physical or pressure blockage in their lumina as well as obstructive processes within the space of Disse. The intimate relationship of the liver sinusoids to neighbouring hepatocytes is a significant factor affecting the health of hepatocytes, or transmission of the effects of injury within the sinusoidal space. Pathologists should recognize several patterns of injury involving the sinusoids and surrounding hepatocytes. In this review, injury, alterations and accumulations within the liver sinusoids are illustrated and discussed.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Canada</li><li>France</li><li>Grèce</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Attique (région)</li><li>Groningue (province)</li><li>Latium</li><li>Maryland</li><li>Midlands de l'Ouest</li><li>Vienne (Autriche)</li></region><settlement><li>Athènes</li><li>Baltimore</li><li>Birmingham</li><li>Groningue</li><li>Rome</li><li>Vienne (Autriche)</li></settlement></list><tree><country name="États-Unis"><noRegion><name sortKey="Brunt, Elizabeth M" sort="Brunt, Elizabeth M" uniqKey="Brunt E" first="Elizabeth M" last="Brunt">Elizabeth M. Brunt</name></noRegion><name sortKey="Brunt, Elizabeth M" sort="Brunt, Elizabeth M" uniqKey="Brunt E" first="Elizabeth M" last="Brunt">Elizabeth M. Brunt</name><name sortKey="Goodman, Zachary D" sort="Goodman, Zachary D" uniqKey="Goodman Z" first="Zachary D" last="Goodman">Zachary D. Goodman</name><name sortKey="Torbenson, Michael S" sort="Torbenson, Michael S" uniqKey="Torbenson M" first="Michael S" last="Torbenson">Michael S. Torbenson</name><name sortKey="Torbenson, Michael S" sort="Torbenson, Michael S" uniqKey="Torbenson M" first="Michael S" last="Torbenson">Michael S. Torbenson</name></country><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Gouw, Annette S H" sort="Gouw, Annette S H" uniqKey="Gouw A" first="Annette S H" last="Gouw">Annette S H. Gouw</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hubscher, Stefan G" sort="Hubscher, Stefan G" uniqKey="Hubscher S" first="Stefan G" last="Hubscher">Stefan G. Hubscher</name></region><name sortKey="Tiniakos, Dina G" sort="Tiniakos, Dina G" uniqKey="Tiniakos D" first="Dina G" last="Tiniakos">Dina G. Tiniakos</name></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Tiniakos, Dina G" sort="Tiniakos, Dina G" uniqKey="Tiniakos D" first="Dina G" last="Tiniakos">Dina G. Tiniakos</name></region></country><country name="France"><noRegion><name sortKey="Bedossa, Pierre" sort="Bedossa, Pierre" uniqKey="Bedossa P" first="Pierre" last="Bedossa">Pierre Bedossa</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Burt, Alastair D" sort="Burt, Alastair D" uniqKey="Burt A" first="Alastair D" last="Burt">Alastair D. Burt</name></noRegion><name sortKey="Clouston, Andrew D" sort="Clouston, Andrew D" uniqKey="Clouston A" first="Andrew D" last="Clouston">Andrew D. Clouston</name></country><country name="Italie"><region name="Latium"><name sortKey="Callea, Francesco" sort="Callea, Francesco" uniqKey="Callea F" first="Francesco" last="Callea">Francesco Callea</name></region></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Dienes, Hans P" sort="Dienes, Hans P" uniqKey="Dienes H" first="Hans P" last="Dienes">Hans P. Dienes</name></region></country><country name="Canada"><noRegion><name sortKey="Roberts, Eve A" sort="Roberts, Eve A" uniqKey="Roberts E" first="Eve A" last="Roberts">Eve A. Roberts</name></noRegion><name sortKey="Wanless, Ian R" sort="Wanless, Ian R" uniqKey="Wanless I" first="Ian R" last="Wanless">Ian R. Wanless</name></country><country name="Belgique"><noRegion><name sortKey="Roskams, Tania" sort="Roskams, Tania" uniqKey="Roskams T" first="Tania" last="Roskams">Tania Roskams</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Terracciano, Luigi" sort="Terracciano, Luigi" uniqKey="Terracciano L" first="Luigi" last="Terracciano">Luigi Terracciano</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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